익모초 강압 고혈압효과 고혈압치료

익모초(益母草) 추출액이 국소 뇌혈류량 및 평균혈압에 미치는 영향

[논문]익모초(益母草) 추출액이 국소 뇌혈류량 및 평균혈압에 미치는 영향 (kisti.re.kr)

Abstract
The study was designed to investigate the effects of Leonuri herba extract (LHE) on the change of regional cerebral blood flow (rCBF) and mean arterial blood pressure (MABP) in normal rats, and further to determine the mechanism of action of LHE. The results in normal rats were as follows, LHE significantly increased rCBF in a dose-dependent manner, and MABP did not change in a dose-dependent manner. This results were suggested that LHE significantly increased rCBF by dilating pial arterial diameter. The LHE-induced increase in rCBF was significantly inhibited by Pretreatment with indomethacin(1 mg/kg, i.p.), an inhibitor of cyclooxygenase, and was significantly inhibited by methylene blue(10μg/kg, i.p.), an inhibitor of guanylate cyclase. The LHE-induced MABP did not change by pretreatment with indomethacin but was significantly inhibited by methylene blue. This results were suggested that the mechanism of LHE was mediated by cyclooxygenase.

[논문]익모초(益母草) 추출물이 뇌허혈 흰쥐의 뇌혈류량 및 사이토카인에 미치는 효과 (kisti.re.kr)

Abstract
The study was designed to investigate the effects of Leonuri herba extract (LHE) on the change of regional cerebral blood flow (rCBT and cytokines production (IL-1β, TNF-α, IL-10, TGF-β) in ischemic rats. The results were as follows : The rCBF was significantly and stably increased by LHE (10 mg/kg, i.p.) during the period of cerebral reperfusion, which contrasted with the findings of rapid and marked increase in control group. In cytokine production of serum by drawing from femoral arterial blood at 1 hr after middle cerebral arterial occlusion, experimental group (LHE 10 mg/kg treated group) was significantly decreased IL-lβ production, and increased TGF-β production compared with control group. In cytokine production of serum by drawing from femoral arterial blood at 1 hr after reperfusion, experimental group was significantly decreased IL-1β production compared with control group. IL-10 and TGF-β production of sample group were significantly increased compared with control group. These results suggested that LHE was significantly and stably increased regional cerebral blood flow by inhibited IL-1β production, and accelerated IL-10 and TGF-β production.

KR100845338* 익모초 추출물을 함유하는 고혈압의 예방 및 치료용약학조성물 (wipo.int)

KO) 익모초 추출물을 함유하는 고혈압의 예방 및 치료용약학조성물
 

요약서

(EN) PURPOSE: A composition comprising an extract of Leonurus heterophyllus Sweet. is provided to inhibit blood pressure from increasing effectively by inhibiting ACE (angiotensin converting enzyme), thereby being usefully used to prevent and treat hypertension. CONSTITUTION: A pharmaceutical composition for preventing and treating hypertension comprises an extract of Leonurus heterophyllus Sweet., which is prepared by extracting the Leonurus heterophyllus Sweet. with water or 70% ethanol at a temperature of 10-150 deg.C for 3-12 hours, as an effective ingredient. A health functional food for preventing and improving the hypertension comprises the extract of Leonurus heterophyllus Sweet.. ©KIPO 2008
 

(KO) 본 발명은 익모초(.) 추출물을 함유하는 조성물에 관한 것으로, 본 발명의 익모초 추출물은 ACE(안지오텐신 전환효소)를 저해함으로써 안지오텐신 전환효소의 작용으로 발생하는 혈압상승을 효과적으로 억제할 뿐만 아니라, 인체에 대한 안전성이 높으므로, 이를 함유하는 조성물은 고혈압의 예방 및 치료용 약학 조성물 및 건강기능식품으로 유용하게 이용될 수 있다. Leonurus heterophyllus Sweet